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| Football |
| 9.4.2021 – Windham 47, Brunswick 8 |
| 9.4.2021 – Fryeburg Academy 38, Medomak Valley 0 |
| 9.4.2021 – Freeport 33, Carrabec/Madison Co-op 0 |
| 9.4.2021 – Gardiner 35, Old Town 6 |
| 9.4.2021 – Camden Hills 52, Orono 6 |
| 9.4.2021 – Cony 36, Skowhegan 35 |
| 9.4.2021 – Schenck/Stearns 48, Mount View 42 |
| 9.4.2021 – Telstar 62, Traip Academy 6 |
| 9.4.2021 – Waterville 60, Dexter 24 |
| 9.4.2021 – Westbrook/Waynflete 14, Nokomis 7 |
| 9.4.2021 – Cheverus 54, Yarmouth 8 |
| |
| Soccer - Boys |
| 9.4.2021 – Bangor Christian 5, Searsport 0 |
| 9.4.2021 – Bucksport 6, Mattanawcook Academy 0 |
| 9.4.2021 – George Stevens 6, Houlton 3 |
| 9.4.2021 – John Bapst 10, Old Town 1 |
| 9.4.2021 – Falmouth 6, Sanford 0 |
| 9.4.2021 – Winslow 4, Maine Central Institute 0 |
| |
| Soccer - Girls |
| 9.4.2021 – Cheverus 2, South Portland 0 |
| 9.4.2021 – Houlton 6, George Stevens 0 |
| 9.4.2021 – Old Town 1, John Bapst 0 |
| 9.4.2021 – Kennebunk 3, Noble 0 |
| 9.4.2021 – Presque Isle 5, Mount Desert Island 2 |
| 9.4.2021 – Orono 4, Washington Academy 2 |
| 9.4.2021 – Bangor 6, Skowhegan 0 |
| 9.4.2021 – Maine Central Institute 3, Winslow 0 |
| 9.4.2021 – York 2, Freeport 1 |
| |
| Field Hockey |
| 9.4.2021 – Brunswick 7, Lincoln Academy 0 |
| 9.4.2021 – Falmouth 4, Kennebunk 1 |
| 9.4.2021 – Lawrence 2, Belfast 0 |
| 9.4.2021 – Maine Central Institute 19, Mount View 0 |
| 9.4.2021 – Biddeford 9, Sanford 0 |
| 9.4.2021 – Scarborough 8, Portland/Deering 0 |
| 9.4.2021 – Windham 6, South Portland 0 |
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